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10.1186/s13073-021-00851-9 Genome Med
The design rationale was elegant: full human growth hormone produces complex systemic effects, many of which are undesirable in a fat loss context (insulin resistance, tissue growth effects, IGF-1 elevation)
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In mouse models of type 2 diabetes induced by a highfat diet and streptozotocin, 4 weeks of 5amino1mq injection reduced fasting blood glucose by 25%30%, increased insulin secretion by over 20%, and significantly decreased cell apoptosis
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